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Musculoskeletal Diagnosis


The many musculoskeletal dilemmas faced by the health care
practitioner on a daily basis challenge the caregiver to provide
the most appropriate therapeutic intervention. Advances in
medical research have stuffed the practitioner’s medicine bag
with a myriad of treatment options. As a result, statistically
significant successful outcomes continue to increase in
frequency. The new millennium has brought heightened public
attention to and awareness of physical fitness and general wellbeing.
Many are increasingly diet conscious, others pay close
attention to workout schedules, and the majority of people
enjoy a lengthened life expectancy.
Apace with the fitness craze, the medical profession continues
to see a rise in musculoskeletal injuries. Although most—such
as sprains and strains—are minor, others are more significant,
including fractures and head injuries. The common denominator
in evaluating and treating these maladies is the establishment of
a clear and precise working diagnosis. When the health care
practitioner has resources available to derive the working
diagnosis, the ensuing work-up is simplified.
The Pocket Guide to Musculoskeletal Diagnosis is just such
a resource. Author Grant Cooper has systematically written a
practical guide to assist the medical clinician in establishing a
working diagnosis, and he offers appropriate work-up and treatment
options for many musculoskeletal ailments. The guide is
sectioned by body region and maintains superb clarity, consistency,
and organization in its writing. This comprehensive guide
allows the busy practitioner to have at hand a resource that raises
awareness not only of specific diagnoses, but also associated
maladies inclusive in the differential diagnosis.
This guide is one I will recommend not only to young
physicians in training, but also to my peers and colleagues.
Robert S. Gotlin, DO
Director, Orthopaedic & Sports Rehabilitation
Director, Sports and Spine Rehabilitation Fellowship Program
Beth Israel Medical Center
New York, NY
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Clinical Skills for OSCE 2nd Edition


Clinical skills exams, such as Objective Structured Clinical Examinations (OSCEs), are a daunting but essential component of medical undergraduate education. To prepare for these exams, our generation of medical students had to pull together vast amounts of information from maladapted resources. This tedious and time· consuming process can now be avoided, as all this information has been compiled into
this one, handy book. Indeed, this book covers all the clinical skills that are likely to be tested during the
clinical years of a medical course. Although il aims to be comprehensive and detailed, its primary purpose is to be easy to read and to the point. Clinical Skills for OSCEs does not attempt to teach its reader medicine or surgery, but rather gathers and organises a large amount of information and presents it in a structured and memorable fashion. We hope you find Clinical Skills for OSCEs useful both for your revision and for the
consolidation of skills learnt at the patient's bedside. Neell Burton

Akbar H de' Medici
Nicholas C Stacey
london, August 2002
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Atlas of Clinica Diagnosis


The traditional teaching of clinical medicine by the
bedside, by lectures, tutorials and through textbooks is
mainly system- and disease-oriented. Diseases are presented
under their relevant system headings and all the
clinical manifestations, irrespective of their regional and
anatomical diversity, are presented under each disease.
This discipline of learning clinical medicine is contrary
to how it is practised in real life, where the history and
examination may have to be constructed on a single
symptom or an asymptomatic sign. The patient presents
with one or more symptoms and the examiner, during
history-taking and clinical examination, takes note of
various signs that are present and constructs a diagnosis
from these.
In this book I have endeavoured to mirror life and have
presented signs as they are likely to be seen on a visual
survey of a patient, starting at the face and moving down
step-by-step to the feet. A brief description of each disease
is given as the part of the body it affects is covered in
the sequence of the scalp-to-sole survey, and with each
mention of a condition a few more details are added. The
book explores the visual content of clinical medicine and
covers both pathognomonic and fundamental signs as well
as non-specific signs. These clinical features presented in
an anatomical context will, hopefully, offer an iterative
stimulus to the student's memory and thereby help the
retentive ability of the reader. Thus, this atlas presents the
synthesis of a clinical diagnosis from the features scattered
around the body and encourages the student to look for
these.
In this age of 'superspecialization', it is becoming
increasingly difficult for undergraduates as well as postgraduate
students anywhere in the world to see the full
spectrum of clinical signs. The increasing demands on the
clinical curriculum from the advancing old specialities and
emerging new ones have reduced the time available to students
to experience the full breadth of clinical medicine.
Today it is quite usual to find students graduating from
various medical schools in this and other countries with no
clinical instruction in, for example, dermatology, rheumatology
or neurology! This problem is compounded by the
fact that many diseases are often treated early, more effectively
and now, more often, in the community. There are
fewer opportunities for students to see the usual and less
common signs, and yet they are likely to be confronted
with these signs in examination and in their subsequent
clinical practice. In this book I have addressed this problem
by covering as much neurology, dermatology, rheumatology
and ophthalmology as may confront a hospital doctor
and a general practitioner. In addition to the colour pictures
of the clinical signs of each condition presented here,
anatomical sketches and line diagrams have been included,
wherever appropriate, both to improve the understanding
of clinical features and to cover some important, but nonvisual
signs.
This book presents a structured approach to clinical
diagnosis from a single sign, suggests other areas to look
at for relevant supplementary signs and, at appropriate
places, gives the critical 'chairside' tests to confirm a diagnosis.
This approach makes some repetition inevitable, but
this has been kept to a minimum and the clinical signs have
been cross-referenced for easy revision.
When I started work on the first edition of this book
my main objective was to present a pictorial guide for
the inspection part of the clinical assessment. Some of
my well-wisher colleagues had expressed understandable
doubt about the success of such a venture in an age
when technology makes it possible to see the condition of
almost any internal organ. Contemporary clinical practice
tends to suggest that the budding clinician of today
would much rather get an ultrasound of the abdomen
than spend time at looking at its external contours. I felt
that my modest effort would at least serve those students
whose self-esteem would not allow them to dispense with
what their eyes could do before calling technology to their
aid. It is pleasing to note that in the UK and USA 12,000
copies have been sold and the book was translated into
seven languages. Bedside medicine is not dead after all! I
am grateful to all those who have found this book of some
use and have encouraged me to produce the second
edition.
In introducing some embellishments I have taken advice
mainly from students who have generously given their
comments to me. In the first edition, I had omitted the
legends because I thought that students would have a
chance to make their own observations before reading the
text to look for the diagnosis. I am told that it would be
preferable to have the legends giving the telling feature of
each picture, and that it would also help students to apply
appropriate descriptive terms. In addition to providing the
legends, I have made some amendments and additions to
the text. I have withdrawn seven pictures that were either
repetitive or unsatisfactory, replaced eight others with
those with more expressive visual content, and introduced
39 pictures with additional signs. I hope the students will
find these changes useful.
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Basic and Clinical Pharmacology Katzung

this book is designed to provide a complete and current and readable pharmacology textbook for student in medicine. so grab it fast!
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Handbook of Psychiatric Drugs


There is little question that this is the most exciting time in history to be involved in the treatment of patients with psychiatric disorders. The explosive growth in our knowledge base in all areas of the field, particularly in neuroscience, has revolutionized both our understanding of the nature of psychiatric illnesses and our ability to provide effective treatments. As molecular genetics and pharmacology, neurochemistry,
and new drug discovery techniques continue to advance, physicians are faced with the need to assimilate an everchanging body of knowledge. In particular, the change in pharmacotherapy for psychiatric illnesses continues at a dizzying pace. We have been very gratified by the extremely positive international
response to our major textbook, Psychiatry, Second Edition (Tasman, A, Kay, J, Lieberman, JA, Wiley, 2003). We believe, however, that busy clinicians need a quick reference guide to the most up-to-date information on prescribing medications for psychiatric illnesses. This book, the Handbook of Psychiatric Drugs, is based on the outstanding chapters on pharmacotherapy in Psychiatry, Second Edition. The material has been condensed, updated to just months before publication, and organized by specific classes of medications. To enhance the daily utility of this handbook, we chose a format that emphasized ease of use, and ensured that each chapter follows a specific template of topics, including the pharmacology, mechanism of action and pharmacokinetics, indications and methods of prescribing, side effects and drug
interactions, and descriptions of each specific drug within the class. We have aimed to include prescription medications in common use anywhere in the world. Further, each chapter was then reviewed by highly respected psychiatrists with pharmacotherapy expertise in that particular class of medication.

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Handbook of Drugs for tropical Infections


The second edition of Handbook of Drugs for Tropical Parasitic Infections is a product from the Unit of Tropical Pharmacology at the Department of Clinical Pharmacology, Huddinge University Hospital. The unit is a collaborative venture between the Departments of Infectious Diseases and Clinical Pharmacology, and
the Hospital Pharmacy. Our department has been involved for many years in research on drugs used in the treatment of tropical parasitic infections. The emphasis has been to develop and apply new bioanalytical techniques to study the clinical pharmacokinetics and metabolites of old and new drugs. Research fellows from Africa, Asia, and South America have participated in this work giving us important feedback from areas where tropical diseases are endemic. Dr Yakoub Aden Abdi from Somalia is one of these past fellows who has devoted his research on the reevaluation of old antiparasitic drugs. It is an honour that he and his Swedish colleagues asked me to write this Preface. During the past 40 years novel drugs have been introduced for diseases that were in the past the cause of death of thousands of people. Advances in the field
of clinical pharmacology have contributed to a safer and more effective use of both old and new drugs and thereby to better patient care. In particular, new knowledge about genetic and environmental determinants of drug metabolism in humans has made it possible to introduce rational strategies in drug treatment. Pharmacoepidemiology, a science concerned with epidemiological aspects of the safety and efficacy of drug products and their utilization in the population, has also grown in importance in recent years. Developed and less developed countries seem to share a number of problems leading to irrational drug use such as old fashioned teaching in pharmacology, drug information that is productrather than problem-oriented and increasing criticism among patients and politcians about how drugs are being prescribed by physicians.
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Goodman and Gilmans Pharmacological


Upon learning that I was assuming the editorship of this book, a senior colleague warned, "Be careful. Don't tamper lightly with the bible." This reputation of "G & G" as the "bible of pharmacology" is a tribute to the ideals and writing of the original authors, Alfred Gilman and Louis Goodman. In 1941, they set forth the principles that have guided this book through ten prior editions and that the associate editors and I have continued to use: to correlate pharmacology with related medical sciences, to re-interpret the actions and uses of drugs in light of advances in medicine and the basic biomedical sciences, to emphasize the applications of pharmacodynamics to therapeutics, and to create a book that will be useful to students of pharmacology and physicians alike.

As with all editions since the second, expert scholars have written the individual chapters, a number of which are new to this edition. We have emphasized basic principles, adding chapters on drug transporters and drug metabolism; the material covered in these chapters explains many prominent drug-drug interactions and adverse drug responses. We have also added a chapter on the emerging field of pharmacogenetics, looking toward the individualization of therapy and an understanding of how our genetic make-up influences our responses to drugs. A chapter entitled "The Science of Drug Therapy" describes how basic principles of pharmacology apply to the care of the individual patient. Most other chapters have been extensively revised; a few have been condensed or eliminated.

Assembling a multi-author pharmacology book challenges contributors and editors in different ways. Among the apparently irresistible and understandable temptations in writing a chapter are the desire to cover everything, the urge to explain G-protein coupled signaling, and the inclination to describe in detail the history of the field in which one is an expert, citing all relevant papers from Claude Bernard to the present. These hazards, plus the continuing advance of knowledge, produce considerable pressure to increase the length of the book. As an antidote, the associate editors and I have worked to eliminate repetition and extraneous text. We have pressed contributors hard, using the communicative rapidity and ease of e-mail to interact with them, to clarify and condense, and to re-write while adhering to the principles of the original authors and retaining the completeness for which the book is known. We have tried to standardize the organization of chapters; thus, students should easily find the physiology and basic pharmacology set forth in regular type in each chapter, and the clinician and expert will find details in extract type under identifiable headings. We have also tried to improve the clarity of tables and figures to provide summaries of concepts and large amounts of information. Although this 11th edition is slightly shorter than its predecessor, we believe that it is every bit as thorough.

Many deserve thanks for their contributions to the preparation of this edition. Professors Keith Parker (UT Southwestern) and John Lazo (U. Pittsburgh) have lent their considerable energy and expertise as associate editors. Professor Nelda Murri (U. Washington) has read each chapter with her keen pharmacist's eye. Two Nashville novelists played essential roles: Lynne Hutchison again served ably as managing editor, coordinating the activities of contributors, editors, and word processors; and, for the second time, Chris Bell checked references and assembled the master copy. Each chapter has been read by an expert in addition to the editors, and the editors thank those readers. We also express our appreciation to former contributors, who will, no doubt, recognize some of their best words from previous editions. We are grateful to our editors at McGraw-Hill, Janet Foltin and James Shanahan, who have shepherded the edited text into print, and to our wives, whose support and forbearance are gifts beyond reckoning. Lastly, I would like to pay tribute to my friend, Alfred G. Gilman. As a teacher, mentor, researcher, editor of several editions of this book, Nobel laureate, chair of a distinguished pharmacology department, and now dean of a medical school, he has enriched every aspect of our field.

Laurence Brunton
SAN DIEGO, CALIFORNIA
JULY 1, 2005

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Pocket Clinical Drug Reference


Davis’s Pocket Clinical Drug Reference is a quick resource for the most commonly used drugs in clinical practice. The monographs are designed to highlight pertinent information; specifically, each monograph
includes a drug’s generic name, brand name, therapeutic indication, pharmacologic class, pregnancy class, contraindications, adverse drug reactions, drug interactions, dose, availability, and monitoring
parameters. To incorporate as many drugs as possible into a pocket drug guide format, only the most common adverse drug reactions and drug interactions are presented within each monograph. The table entitled Cytochrome P450 Substrates/Inhibitors/Inducers (page 285) provides more specific information regarding the drugs that may be involved in certain drug interactions. Additionally, within each monograph, a Notes section is included to highlight miscellaneous information that users should consider when initiating or monitoring drug therapy in their patients. In the Appendix, a number of useful tables and charts, covering
topics such as immunization guidelines, intravenous drugs, and narcotic equianalgesic dosing guidelines, provide additional information that is relevant to clinical practice. To obtain detailed drug information beyond what is supplied in the monographs of this pocket drug guide, the user should refer to the medical literature or the complete product information supplied by the manufacturer.

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