Color Atlas of Hematology

Our Current Edition
Although this is the second English edition of our hematology atlas, this
edition is completely new. As an immediate sign of this change, there are
now three authors. The completely updated visual presentation uses digital
images, and the content is organized according to the most up-to-date
morphological classification criteria.
In this new edition, our newly formed team of authors from Munich
(the “Munich Group”) has successfully shared their knowledge with you.
Heinz Diem and Torsten Haferlach are nationally recognized as lecturers
of the diagnostics curriculum of the German Association for Hematology
and Oncology

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Atlas of Clinical Hematology

The first edition of the Atlas of Clinical Hematology was published over 40 years ago. The first four editions were coauthored by Herbert Begemann, who died unexpectedly in April of 1994. We wish to dedicate the fifth edition as a memorial to this dedicated physician and hematologist. Since the fourth edition was published in 1987, hematology has undergone profound changes. New methods such as cytochemistry and immunophenotyping have been joined by cytogenetics and, more recently, molecular genetic techniques, which have assumed a major role in routine diagnostic procedures. This has been due in part to significant advances in methodology and new tools in molecular biology. When used in standardized protocols, these tools can furnish swift results that are relevant to patient care. Since the advent of cytogenetics and molecular genetics, we have formulated new definitions for clinical and biological entities. An example is promyelocytic leukemia with its two variants (M3 and M3v), the (15;17) translocation, and the PML/RARA fusion gene, which has been successfully treated for the first time with differentiation therapy. Another example is acute myelomonocytic leukemia with abnormal eosinophiles (M4Eo), inversion 16, and the MYH/11/

CBFB fusion gene, which has a very good prognosis. The transmission of morphologic findings by electronic data transfer is also gaining importance in hematology, as it permits the immediate review of difficult findings by specialists. Several colleagues seated at their own desks and microscopes can communicate with one another instantaneously by computer monitor. These advances do not alter the fact that hematologists must still have a sound grasp of morphologic principles. Diagnostic problems often arise when modern counting devices and cell sorters, with their impressive capabilities, are used without regard for cellular morphology. There is no question that classical morphology has gained much from its competition and comparison with the new techniques, leading to significant diagnostic and prognostic advances. While retaining the basic concept of the previous editions, we found it necessary to eliminate several chapters. Now that many hematologic centers and laboratories are equipped with fluorescence-activated cell sorters (FACS) for immunotyping, and given the availability of reliable commercial kits and precise staining instructions for immunocytochemistry, the chapter by B. R. Kranz has been omitted from the present edition. We have also

dropped the methodology section and most of the electron micrographs supplied by Prof. D. Huhn. Both colleagues merit our sincere thanks. Ever since the first edition, Prof. W. Mohr of Hamburg has authored the chapter on blood parasites as the principal causative agents of tropical diseases, and we gratefully acknowledge his contribution. Following the death of Prof. Mohr, we have chosen to include this chapter owing to the special importance of tropical diseases in the modern world. We are grateful to Prof. R.

Disko of Munich, who agreed to revise and update the chapter.

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Color Atlas of Genetics

The aim of this book is to give an account of the scientific field of genetics based on visual displays of selected concepts and related facts. Additional information is presented in the introduction,

with a chronological list of important discoveries and advances in the history of genetics, in an appendix with supplementary data in tables, in an extensive glossary explaining genetic terms, and in references, including

websites for further in-depth studies. This book is written for two kinds of readers: for students

of biology and medicine, as an introductory overview, and for their mentors, as a teaching aid. Other interested individuals will also be able to gain information about current developments and achievements in this rapidly growing field. Gerhardus

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Molecular Cell Biology

Like ourselves, the individual cells that form our bodies can grow, reproduce, process information, respond to stimuli, and carry out an amazing array of chemical reactions. These abilities define life. We and other multicellular organisms contain billions or trillions of cells organized into complex structures, but many organisms consist of a single cell. Even simple unicellular organisms exhibit all the hallmark properties of life, indicating that the cell is the fundamental unit of life. As the twenty-first century opens, we face an explosion of new data about the components of cells, what structures they contain, how they touch and influence each other. Still, an immense amount remains to be learned, particularly about how information flows through cells and how they decide on the most appropriate ways to respond. Molecular cell biology is a rich, integrative science that brings together biochemistry, biophysics, molecular biology, microscopy, genetics, physiology, computer science, and developmental biology. Each of these fields has its own emphasis and style of experimentation. In the following chapters, we will describe insights and experimental approaches drawn from all of these fields, gradually weaving the multifaceted story of the birth, life, and death of cells. We

start in this prologue chapter by introducing the diversity of cells, their basic constituents and critical functions, and what we can learn from the various ways of studying cells.

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Medical Biochemistry

Human metabolism is a key component of the basic science knowledge that underlies the practice of medicine and allied health professions. It is fundamental to understanding how the body adapts to physiologic stress, how defects in metabolism result in disease, and why data from the clinical chemistry laboratory are useful to diagnose disease and monitor the efficacy of treatment. Over the more than three decades that each of the authors has been teaching biochemistry to medical students, we have found students increasingly overwhelmed with details that tend to obscure rather than elucidate principles of human metabolism. Our main aim in writing this book was to provide students in the health professions with a concise resource that will help them understand and appreciate the functions, constituent reactions, and regulatory aspects of the core pathways that constitute human metabolism and which are responsible for maintaining homeostasis

and well-being in humans. We have tried to accomplish this by emphasizing function, regulation, and disease processes, while minimizing discussion of reaction mechanisms and details of enzyme structure. Each chapter is organized in a consistent manner beginning with an explanation of the main functions of the pathway under discussion. Next comes a brief accounting of the cells, tissues, and organs in which the pathway is expressed and the conditions under which the normal function of the pathway is especially important. The bulk of each chapter is devoted to the reactions that account for the function of the pathway, with emphasis on key steps in the pathway. The next section of each chapter discusses the ways in which the activity of the pathway is regulated by hormones, genetic factors, or changes in the intracellular concentration of key metabolites. Each

chapter concludes with a discussion of the more common and illustrative diseases that result from defects in or derangements of regulation of the pathway.

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Basic Medical Biochemistry Marks

Marks’ Basic Medical Biochemistry: A Clinical Approach, 2nd Edition
·  Chapter 1: Metabolic Fuels and Dietary Components
·  Chapter 2: The Fed or Absorptive State
·  Chapter 3: Fasting
·  Chapter 4: Water, Acids, Bases, and Buffers
·  Chapter 5: Structures of the Major Compounds of the Body
·  Chapter 6: Amino Acids in Proteins
·  Chapter 7: Structure–Function Relationships in Proteins
·  Chapter 8: Enzymes as Catalysts
·  Chapter 9: Regulation of Enzymes
·  Chapter 10: Relationship Between Cell Biology and Biochemistry
·  Chapter 11: Cell Signaling by Chemical Messengers
·  Chapter 12: Structure of the Nucleic Acids
·  Chapter 13: Synthesis of DNA
·  Chapter 14: Transcription: Synthesis of RNA
·  Chapter 15: Translation: Synthesis of Proteins
·  Chapter 16: Regulation of Gene Expression
·  Chapter 17: Use of Recombinant DNA Techniques in Medicine
·  Chapter 18: The Molecular Biology of Cancer
·  Chapter 19: Cellular Bioenergetics: ATP And O2
·  Chapter 20: Tricarboxylic Acid Cycle
·  Chapter 21: Oxidative Phosphorylation and Mitochondrial Function
·  Chapter 22: Generation of ATP from Glucose: Glycolysis
·  Chapter 23: Oxidation of Fatty Acids and Ketone Bodies
·  Chapter 24: Oxygen Toxicity and Free Radical Injury
·  Chapter 25: Metabolism of Ethanol
·  Chapter 26: Basic Concepts in the Regulation of Fuel Metabolism by Insulin, Glucagon, and Other
Hormones
·  Chapter 27: Digestion, Absorption, and Transport of Carbohydrates
·  Chapter 28: Formation and Degradation of Glycogen
·  Chapter 29: Pathways of Sugar Metabolism: Pentose Phosphate Pathway, Fructose, and Galactose
Metabolism
·  Chapter 30: Synthesis of Glycosides, Lactose, Glycoproteins and Glycolipids
·  Chapter 31: Gluconeogenesis and Maintenance of Blood Glucose Levels
·  Chapter 32: Digestion and Transport of Dietary Lipids
·  Chapter 33: Synthesis of Fatty Acids, Triacylglycerols, and the Major Membrane Lipids
·  Chapter 34: Cholesterol Absorption, Synthesis, Metabolism, and Fate
·  Chapter 35: Metabolism of the Eicosanoids
·  Chapter 36: Integration of Carbohydrate and Lipid Metabolism
·  Chapter 37: Protein Digestion and Amino Acid Absorption
·  Chapter 38: Fate of Amino Acid Nitrogen: Urea Cycle
·  Chapter 39: Synthesis and Degradation of Amino Acids
·  Chapter 40: Tetrahydrofolate, Vitamin B12, And S-Adenosylmethionine
·  Chapter 41: Purine and Pyrimidine Metabolism
·  Chapter 42: Intertissue Relationships in the Metabolism of Amino Acids
·  Chapter 43: Actions of Hormones That Regulate Fuel Metabolism
·  Chapter 44: The Biochemistry of the Erythrocyte and other Blood Cells
·  Chapter 45: Blood Plasma Proteins, Coagulation and Fibrinolysis
·  Chapter 46: Liver Metabolism
·  Chapter 47: Metabolism of Muscle at Rest and During Exercise
·  Chapter 48: Metabolism of the Nervous System
·  Chapter 49: The Extracellular Matrix and Connective Tissue

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Instant Notes Biochemistry

It was perhaps a mark of how successful the second edition of Instant Notes in Biochemistry was that we

recall seeing a final year student avidly reading it even as he waited to have his viva with the External

Examiner. Although we would strongly recommend to any student not to leave revision to such a very

late stage, this experience alone proved the value of a concise book that focused on essential biochemical

information in an easily accessible format! Let us be clear. This is not a book to replace the superb all-embracing and highly detailed Biochemistry textbooks that take the reader to the cutting edge of this science. Rather, its goal is to allow the reader to cut to the heart of the matter, to see what the core information is and readily to assimilate it. For mainstream Biochemistry students, it may be seen as complementary to the large

detailed textbooks, whereas for students taking Biochemistry as an optional or elective module, it

should be welcome as a fast way to become acquainted with the main facts and concepts.

This book is aimed at supporting students primarily in the first and second years of their degree,

although, as we recount above, it can also serve as a welcome friend when faced with certain adverse

situations even in the final year! The third edition has taken on board all of the many comments and

advice that we have gratefully received from readers and academic colleagues alike, and we have

corrected a number of errors, omissions and ambiguities. No doubt we have still missed a few; do let

us know of any that you spot. This revision has necessarily reflected the many new directions that

Biochemistry has taken since the last edition, whilst also preserving coverage of the core of the subject.

The book now also includes expanded coverage of cell structure and imaging, proteomics, microarrays,

signal transduction, etc. As with earlier editions, we have been careful to include only the information

that we believe is essential for good student understanding of the subject – and for rapid revision when

exams appear on the horizon. Do use the book not only to get to grips with the subject but also as a

ready source of elusive information. We hope and believe that you will find it as useful as past

students told us they found the earlier editions.

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Harper's Illustrated Biochemistry

Medicine is an ever-changing science. As new research and clinical experience broaden our knowledge, changes in treatment and drug therapy are required. The authors and the publisher of this work have checked with sources believed to be reliable in their efforts to provide information that is complete and generally in accord with the standards accepted at the time of publication. However, in view of the possibility of human error or changes in medical sciences, neither the authors nor the publisher nor any other party who has been involved in the preparation or publication of this work warrants that the information contained herein is in every respect accurate or complete, and they disclaim all responsibility for any errors or omissions or for the results obtained from use of the information contained in this work. Readers are encouraged to confirm the information contained herein with other sources. For example and in particular, readers are advised to

check the product information sheet included in the package of each drug they plan to administer to be certain that the information contained in this work is accurate and that changes have not been made in the recommended dose or in the contraindications for administration. This recommendation is of particular importance in connection with new or infrequently used drugs.

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Essential Biochemistry for Medicine Fry

To the uninitiated, biochemistry is a complex and intricate subject, but importantly it is a subject

that underpins the biosciences, including medicine. As a university lecturer, and by training a

biochemist, I have taught my subject to both ‘my own’ students, and to those on allied degree

schemes and pre-clinical medicine. Of course, the lines so conveniently drawn (for teaching

purposes) between the different bio-disciplines are very artificial; there is far more commonality

than difference between these subjects. As a biochemist I am pleased to see the subject have

such eminence, and rightly so, but at the same time it should not be delivered as a fate accompli,

but rather as an aid to understand and clarify, a foundation to build upon and allow explanation.

When I set out to write this book, it was not my intention to write a ‘biochemistry’ text, nor a

‘medical’ text, but rather something that provided a more complete picture. This is not meant to

be a reference work, but rather a companion, and hopefully one that accurately reflects the type,

depth and amount of biochemistry that is appropriate for medical and biomedical undergraduate

students alike.

Essential Biochemistry for Medicine should provide a useful and helpful supplement to

lectures and workshops, a biochemical–physiological–medical continuum, full of numerous

medical examples, additional factual material and FOCUS sections on some favourite medical

topics. I have tried to keep the book simply presented but packed with information, and it contains

a full index to aid quick navigation. Indeed, it may be the only biochemistry book you need.

Mitch Fry

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Color Atlas of Biochemistry

Biochemistry is a dynamic, rapidly growing

field, and the goal of this color atlas is to

illustrate this fact visually. The precise boundaries

between biochemistry and related

fields, such as cell biology, anatomy, physiology,

genetics, and pharmacology, are dif cult

to define and, in many cases, arbitrary. This

overlap is not coincidental. The object being

studied is often the same—a nerve cell or a

mitochondrion, for example—and only the

point of view differs.

For a considerable period of its history, biochemistry

was strongly influenced by chemistry

and concentrated on investigating metabolic

conversions and energy transfers. Explaining

the composition, structure, and metabolism

of biologically important molecules

has always been in the foreground. However,

new aspects inherited from biochemistry’s

other parent, the biological sciences, are

now increasingly being added: the relationship

between chemical structure and biological

function, the pathways of information

transfer, observance of the ways in which

biomolecules are spatially and temporally distributed

in cells and organisms, and an awareness

of evolution as a biochemical process.

These new aspects of biochemistry are bound

to become more and more important.

Owing to space limitations, we have concentrated

here on the biochemistry of humans

and mammals, although the biochemistry of

other animals, plants, and microorganisms is

no less interesting. In selecting the material

for this book, we have put the emphasis on

subjects relevant to students of human medicine.

Themain purpose of the atlas is to serve

as an overviewand to provide visual information

quickly and ef ciently. Referring to textbooks

can easily fill any gaps. For readers

encountering biochemistry for the first time,

some of the platesmay look rather complex. It

must be emphasized, therefore, that the atlas

is not intended as a substitute for a comprehensive

textbook of biochemistry.

As the subject matter is often dif cult to visualize,

symbols, models, and other graphic

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Basic Concepts in Biochemistry

Basic Concepts in Biochemistry: A Student’s Survival Guide is not a conventional book: It is not a review book or a textbook or a problem book. It is a book that offers help in two different ways—help in understanding the concepts of biochemistry and help in organizing your attack on the

subject and minimizing the subject’s attack on you. This book presents what are often viewed as the more difficult concepts in an introductory biochemistry course and describes them in enough detail and in simple enough language to make them understandable. We surveyed first- and second-year medical students at a national student meeting asking them to list, in order, the parts of biochemistry they found most difficult to understand. The winner (or loser), by far, was integration of metabolism. Metabolic control, pH, and enzyme kinetics ran closely behind, with notable mention given to molecular biology and proteins. Biochemistry texts and biochemistry professors are burdened with the task of presenting facts, and the enormity of this task can get in the way of explaining concepts. Since I don’t feel burdened by that necessity, I’ve only outlined most of the facts and concentrated on concepts. My rationale is that concepts are considerably easier to remember than facts and that concepts, if appropriately mastered, can minimize the amount of material that has to be memorized—you can just figure everything out when required. In Basic Concepts in Biochemistry, central concepts are developed in a stepwise fashion. The simplest concepts provide a review of what might have been forgotten, and the more complex concepts present what might not have been realized.

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Principles of Biochemistry Lehninger 4th

Lehninger Principles of Biochemistry, Fourth Edition presents the fundamentals of biochemistry through selected topics, incorporating the most important recent developments and applications into its singular presentation of the field's classic core. The 4th edition of Albert Lehninger's 'Principles of Biochemistry' has been rewritten by David Nelson and Michael Cox is an expansion on the classical biochemistry text, i.e. metabolic biochemistry, to include both structures of macromolecules and molecular biology. Now updated with the human genome project and up to date information on the two newest branches in biology -

proteomics and genomics. The scope of topics now included in biochemistry textbooks, particularly for biology majors, goes beyond metabolic biochemistry, and biochemistry becomes a general topic 'molecular biology'. The use of the word molecular simply refers to the study of biology at the molecular level, although the term molecular biology refers to molecular genetics in particular. The revolutionary advances in genetics -

recombinant technology, sequencing, expression, cloning - leave behind the classical divisions into biochemistry and molecular biology. Both topics are normally included in biochemistry textbooks, while molecular biology textbooks, or cell biology textbooks, usually do not include metabolism. The inclusion of

genetics and physiology topics in biochemistry textbooks comes at the expense of biochemistry of 'exotic'

organisms like plants and microbes (except photosynthesis). It also comes at the expense of central themes of biochemistry such as thermodynamics and enzyme kinetics. They are more and more relegated to the graduate level at colleges, or left to chemistry department's biochemistry courses. Looking at this new Lehninger book is like looking at the major shifts occurring in modern biology. The reader may get a sense that within the next decade, a new branch of biology will have established itself, leaving classical biochemistry behind and developing out of what is now called functional genomics

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